Publication Library
AI Systems in Clinical Healthcare
Description: Background: Artificial intelligence (AI) research in healthcare is accelerating rapidly, with potential applications being demonstrated across various domains of medicine. However, there are currently limited examples of such techniques being successfully deployed into clinical practice. This article explores the main challenges and limitations of AI in healthcare, and considers the steps required to translate these potentially transformative technologies from research to clinical practice. Main body: Key challenges for the translation of AI systems in healthcare include those intrinsic to the science of machine learning, logistical difficulties in implementation, and consideration of the barriers to adoption as well as of the necessary sociocultural or pathway changes. Robust peer-reviewed clinical evaluation as part of randomised controlled trials should be viewed as the gold standard for evidence generation, but conducting these in practice may not always be appropriate or feasible. Performance metrics should aim to capture real clinical applicability and be understandable to intended users. Regulation that balances the pace of innovation with the potential for harm, alongside thoughtful postmarket surveillance, is required to ensure that patients are not exposed to dangerous interventions nor deprived of access to beneficial innovations. Mechanisms to enable direct comparisons of AI systems must be developed, including the use of independent, local and representative test sets. Developers of AI algorithms must be vigilant to potential dangers, including dataset shift, accidental fitting of confounders, unintended discriminatory bias, the challenges of generalisation to new populations, and the unintended negative consequences of new algorithms on health outcomes. Conclusion: The safe and timely translation of AI research into clinically validated and appropriately regulated systems that can benefit everyone is challenging. Robust clinical evaluation, using metrics that are intuitive to clinicians and ideally go beyond measures of technical accuracy to include quality of care and patient outcomes, is essential. Further work is required (1) to identify themes of algorithmic bias and unfairness while developing mitigations to address these, (2) to reduce brittleness and improve generalisability, and (3) to develop methods for improved interpretability of machine learning predictions. If these goals can be achieved, the benefits for patients are likely to be transformational.
Created At: 14 December 2024
Updated At: 14 December 2024
CausaLM Causal Model Explanation Through Counterfactual Language Models
Description: Understanding predictions made by deep neural networks is notoriously difficult, but also crucial to their dissemination. As all machine learning based methods, they are as good as their training data, and can also capture unwanted biases. While there are tools that can help understand whether such biases exist, they do not distinguish between correlation and causation, and might be ill-suited for text-based models and for reasoning about high level language concepts. A key problem of estimating the causal effect of a concept of interest on a given model is that this estimation requires the generation of counterfactual examples, which is challenging with existing generation technology. To bridge that gap, we propose CausaLM, a framework for producing causal model explanations using counterfactual language representation models. Our approach is based on fine-tuning of deep contextualized embedding models with auxiliary adversarial tasks derived from the causal graph of the problem. Concretely, we show that by carefully choosing auxiliary adversarial pre-training tasks, language representation models such as BERT can effectively learn a counterfactual representation for a given concept of interest, and be used to estimate its true causal effect on model performance. A byproduct of our method is a language representation model that is unaffected by the tested concept, which can be useful in mitigating unwanted bias ingrained in the data
Created At: 14 December 2024
Updated At: 14 December 2024
Neurosymbolic AI The 3rd Wave
Description: Current advances in Artificial Intelligence (AI) and Machine Learning (ML) have achieved unprecedented impact across research communities and industry. Nevertheless, concerns about trust, safety, interpretability and accountability of AI were raised by influential thinkers. Many have identified the need for well-founded knowledge representation and reasoning to be integrated with deep learning and for sound explainability. Neural-symbolic computing has been an active area of research for many years seeking to bring together robust learning in neural networks with reasoning and explainability via symbolic representations for network models. In this paper, we relate recent and early research results in neurosymbolic AI with the objective of identifying the key ingredients of the next wave of AI systems. We focus on research that integrates in a principled way neural network-basedlearning with symbolic knowledge representation and logical reasoning. The insights provided by 20 years of neural-symbolic computing are shown to shed new light onto the increasingly prominent role of trust, safety, interpretability and accountability of AI. We also identify promising directions and challenges for the next decade of AI research from the perspective of neural-symbolic systems.
Created At: 14 December 2024
Updated At: 14 December 2024
Law and Regulation Decision Making Algorithms
Description: Weexplorethe promises and challengesof employingsequential decision-making algorithms– such as bandits, reinforcement learning, and active learning– in the public sector. While such algorithms have been heavily studied in settings that are suitable for the private sector (e.g., online advertising), the public sector could greatly benefit from these approaches, but poses unique methodological challenges for machine learning. We highlight several applications of sequential decision-making algorithms in regulation and governance, and discuss areas for further research which would enable them to be more widely applicable, fair, and effective. In particular, ensuring that these systems learn rational, causal decision making policies can be difficult and requires great care. We also note the potential risks of such deployments and urge caution when conducting work in this area. We hope our work inspires more investigation of public-sector sequential decision making applications, which provide unique challenges for machine learning researchers and can be socially beneficial.
Created At: 14 December 2024
Updated At: 14 December 2024
ACE Towards Application-Centric Edge-Cloud Collaborative Intelligence
Description: Intelligent applications based on machine learning are impacting manypartsofourlives. They are required to operate under rigorous practical constraints in terms of service latency, network bandwidth overheads, and also privacy. Yet current implementations running in the Cloud are unable to satisfy all these constraints. The EdgeCloud Collaborative Intelligence (ECCI) paradigm has become a popular approach to address such issues, and rapidly increasing applications are developed and deployed. However, these prototypical implementations are developer-dependent and scenario-specific without generality, which cannot be efficiently applied in largescale or to general ECC scenarios in practice, due to the lack of supports for infrastructure management, edge-cloud collaborative service, complex intelligence workload, and efficient performance optimization. In this article, we systematically design and construct the first unified platform, ACE, that handles ever-increasing edge and cloud resources, user-transparent services, and proliferating intelligence workloads with increasing scale and complexity, to facilitate cost-efficient and high-performing ECCI application development and deployment. For verification, we explicitly present the construction process of an ACE-based intelligent video query application, and demonstrate how to achieve customizable performance optimization efficiently. Based on our initial experience, we discuss both the limitations and vision of ACE to shed light on promising issues to elaborate in the approaching ECCI ecosystem.
Created At: 14 December 2024
Updated At: 14 December 2024