Publication Library
Automated Market Makers - A Stochastic Optimization Approach for Profitable Liquidity Concentration
Description: Concentrated liquidity automated market makers (AMMs), such as Uniswap v3, enable liquidity providers (LPs) to earn liquidity rewards by depositing tokens into liquidity pools. However, LPs often face significant financial losses driven by poorly selected liquidity provision intervals and high costs associated with frequent liquidity reallocation. To support LPs in achieving more profitable liquidity concentration, we developed a tractable stochastic optimization problem that can be used to compute optimal liquidity provision intervals for profitable liquidity provision. The developed problem accounts for the relationships between liquidity rewards, divergence loss, and reallocation costs. By formalizing optimal liquidity provision as a tractable stochastic optimization problem, we support a better understanding of the relationship between liquidity rewards, divergence loss, and reallocation costs. Moreover, the stochastic optimization problem offers a foundation for more profitable liquidity concentration.
Created At: 25 April 2025
Updated At: 25 April 2025
Charting Multiple Courses to Artificial General Intelligence
Description: The paper "Charting Multiple Courses to Artificial General Intelligence" discusses the potential of large language models (LLMs) to achieve artificial general intelligence (AGI) and suggests that while LLMs are promising, they may not be sufficient on their own. The authors argue that there are limitations to relying solely on scaling up LLMs and that alternative AI technologies should also be considered. They emphasize the importance of a multifaceted approach to AI development, advocating for policies that support a variety of potential paths to AGI.
Created At: 25 April 2025
Updated At: 25 April 2025
Quorum - Zero-Training Unsupervised Anomaly Detection using Quantum Autoencoders
Description: Detecting mission-critical anomalous events and data is a crucial challenge across various industries, including finance, healthcare, and energy. Quantum computing has recently emerged as a powerful tool for tackling several machine learning tasks, but training quantum machine learning models remains challenging, particularly due to the difficulty of gradient calculation. The challenge is even greater for anomaly detection, where unsupervised learning methods are essential to ensure practical applicability. To address these issues, we propose Quorum, the first quantum anomaly detection framework designed for unsupervised learning that operates without requiring any training.
Created At: 20 April 2025
Updated At: 20 April 2025
Fully automated construction of three-dimensional finite element simulations from Optical Coherence Tomography
Description: Despite recent advances in diagnosis and treatment, atherosclerotic coronary artery diseases remain a leading cause of death worldwide. Various imaging modalities and metrics can detect lesions and predict patients at risk; however, identifying unstable lesions is still difficult. Current techniques cannot fully capture the complex morphology-modulated mechanical responses that affect plaque stability, leading to catastrophic failure and mute the benefit of device and drug interventions. Finite Element (FE) simulations utilizing intravascular imaging OCT (Optical Coherence Tomography) are effective in defining physiological stress distributions. However, creating 3D FE simulations of coronary arteries from OCT images is challenging to fully automate given OCT frame sparsity, limited material contrast, and restricted penetration depth. To address such limitations, we developed an algorithmic approach to automatically produce 3D FE-ready digital twins from labeled OCT images. The 3D models are anatomically faithful and recapitulate mechanically relevant tissue lesion components, automatically producing morphologies structurally similar to manually constructed models whilst including more minute details. A mesh convergence study highlighted the ability to reach stress and strain convergence with average errors of just 5.9% and 1.6% respectively in comparison to FE models with approximately twice the number of elements in areas of refinement. Such an automated procedure will enable analysis of large clinical cohorts at a previously unattainable scale and opens the possibility for in-silico methods for patient specific diagnoses and treatment planning for coronary artery disease.
Created At: 20 April 2025
Updated At: 20 April 2025
The Dissipation Theory of Aging - A Quantitative Analysis Using a Cellular Aging Map
Description: We propose a new theory for aging based on dynamical systems and provide a data-driven computational method to quantify the changes at the cellular level. We use ergodic theory to decompose the dynamics of changes during aging and show that aging is fundamentally a dissipative process within biological systems, akin to dynamical systems where dissipation occurs due to non-conservative forces. To quantify the dissipation dynamics, we employ a transformer-based machine learning algorithm to analyze gene expression data, incorporating age as a token to assess how age-related dissipation is reflected in the embedding space. By evaluating the dynamics of gene and age embeddings, we provide a cellular aging map (CAM) and identify patterns indicative of divergence in gene embedding space, nonlinear transitions, and entropy variations during aging for various tissues and cell types. Our results provide a novel perspective on aging as a dissipative process and introduce a computational framework that enables measuring age-related changes with molecular resolution.
Created At: 20 April 2025
Updated At: 20 April 2025